LRRN3 and autism: As LRRN3 is located under the linkage peak of interest for IMGSAC families, and there is evidence of an association with the IMMP2L/DOCK4 region in the IMGSAC cohort [44], we considered LRRN3 to be an appealing candidate for ASD susceptibility, despite a previous study failing to find evidence of an association between this gene and autism in their cohorts [45].