SCLC IIIb期和IV期患者TPS、CEA、CYFRA21-1阳性率均无统计学差异。广泛期SCLC患者TPS阳性率显著高于局限期患者(P=0.040),CEA、Pro-GRP在两种分期间无统计学差异。. The gene discussed is GRP; the disease is small cell lung carcinoma.