ERBB2 and breast cancer: In addition, SRCs have been shown to interact with human epidermal growth factor receptor 2 (HER2/erbB2) (Bouras et al. 2001), and overexpression of HER2 and SRC-3 are both associated with a worse prognosis in cases of human breast cancer (Kirkegaard et al. 2007; McIlroy et al. 2006).