A general connective tissue defect is seen in patients with Ehlers-Danlos syndrome [9] (Classical EDS, which results from mutations in the COL5A1 gene [10,11]), who deliver preterm due to CI or as polymorphisms in the collagen 1A1 gene (COL1A1) found in CI patients [12]. Here, COL1A1 is linked to Ehlers-Danlos syndrome.