Using copy-number and sequencing data of a large cohort of 171 breast tumours (38 metastasized, 130 no-metastasis) [31] we observed an increased frequency of losses in those tumours that metastasized for many of the top ranked genes including BCL2 (18% vs 13%), IGFBP7 (11% vs 6%), IGF1 (8% vs 2%) (Additional file 3). This evidence concerns the gene IGF1 and neoplasm.