Of the 133 genes showing the most significant increases in entropy (Additional file 2) several have expression levels that have already been associated with a poor prognosis and distant metastasis in breast cancer (e.g CDC2, CCNB1, MYBL2, MAD2L1) and which have functions related to the cell-cycle and DNA replication [32,33]. The gene discussed is CCNB1; the disease is breast cancer.