TNFSF10 and neoplasm: In an attempt to explain these conflicting results of TRAIL and its pro-apoptotic receptors in CRC, we offer the following explanations: a) differences and heterogeneity in samples studied: sample size, ethnic differences, different Stage groups, tumor site- colon or rectal tumors, type of treatment- surgery and/or chemo/radiotherapy; b) differences in scoring system could be another important reason for this difference.