KRAS and cancer: Alternate approaches to modulate the expression of KRAS isoforms, a greater understanding of the role(s) that each oncoprotein plays in malignant transformation, including the signal transduction pathways affected, is crucial in the development of therapeutic approaches in cancer treatment, which include the use of drugs that target isoform-specific post-translational modifications [40] and of antisense oligonucleotides to modulate alternative splicing [41].