Although TRAIL-R1 lost its statistical significance when included as a prognostic marker in multivariate analysis with p27 and KRAS4A (see Additional File 1 Table S2), this does not argue against the biological role of TRAIL-R1 in CRC as much as it reflects that p27 and KRAS4A are a more powerful predictor of clinical outcome of CRC than TRAIL-R1 expression. This evidence concerns the gene TNFRSF10A and colorectal carcinoma.