In a small cohort of 51 CRC, Oikonomou E et al.[42] have reported a much lower incidence of KRASG12/13 mutations(10%) and have concluded that there is clear correlation between these mutations(KRAS and BRAF) and upregulation of TRAIL-R1 and TRAIL-R2. This evidence concerns the gene TNFRSF10A and colorectal carcinoma.