Both TRAIL-R1 and TRAIL-R2 expression was significantly higher in both colorectal adenomas [TRAIL-R1 96.11 ± 78.82(p = 0.0312); TRAIL-R2 59.17 ± 49.69(p = 0.0027)] and carcinoma [TRAIL-R1 173.91 ± 61.20(P < 0.00001); TRAIL-R2 115.63 ± 95.76(p = < 0.0001)] as compared to normal colorectal mucosa (TRAIL-R1 52.13 ± 42.48; TRAIL-R2 24.57 ± 38.77). This evidence concerns the gene TNFRSF10A and colorectal adenoma.