Antigens like TYRP-gp75, and Mel14-gp90MEL, which are transmembrane proteins not associated with kinase activities, will not promote the ITIM phosphorylation but rather promote the confinement of the antimelanoma Ab and give a selective advantage to the melanoma that express the FcγRIIB1 [60]. The gene discussed is TYRP1; the disease is melanoma.