DSG3 and pemphigus vulgaris: Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease caused by IgG autoantibodies (auto-Ab) against the extracellular domain (ECD) of desmoglein 3 (Dsg3) and Dsg1, desmosomal adhesion molecules present on epidermal keratinocytes [1].