Using Chi square test, comparison of the frequencies of selected HLA-DRB1 alleles in alopecia of less and more than 1 year duration, in relation to IL-4/IgE levels, revealed that IL-4/IgE levels were statistically highly significantly elevated among the HLADRB1*11 positive chronic patients (having general AA susceptibility allele) and among the HLADRB1*07 positive chronic patients (harboring chronicity allele) (Table 6). The gene discussed is HLA-DRB1; the disease is alopecia.