PPARA and obesity due to melanocortin 4 receptor deficiency: Normal WAT is, so, characterised by an anti-inflammatory tissue milieu able to protect from the development of obesity-related inflammation and IR, most likely also due to activity of members of peroxisome proliferator-activated receptor-(PPAR)s (particularly PPAR-α and -γ) and liver X receptor-(LXR) families, molecules involved in nutrient transport and metabolism and able to antagonize inflammatory activity [36, 37].