MTOR and cancer: mTORC2 is composed of mTOR/Rictor/mLST8/SIN1/Protor/Deptor and is generally described as being insensitive to rapamycin/rapalogs, although long-term treatment of about 20% of cancer cell lines with rapamycin/rapalogs leads to dissociation of mTORC2 [34, 35].