A phase 1 clinical trial combining perifosine and UCN-01 (a staurosporine derivative which inhibits PDK1) (NCT00301938) and a phase II clinical trial with perifosine alone (NCT00391560) have been performed in patients with refractory/relapsed AML, but the results have not yet been disclosed. This evidence concerns the gene PDK1 and acute myeloid leukemia.