Furthermore, interactions between β1 integrins on AML cells and stromal fibronectin could lead to pathway activation [92, 93], possibly through up-regulation of integrin-linked kinase 1 (ILK1) which is involved in Akt phosphorylation on Ser473 in a PI3K-dependent manner in AML cells [94]. The gene discussed is AKT1; the disease is acute myeloid leukemia.