Poor prognosis of AML patients with elevated PI3K/Akt/mTOR signaling could be also related to the fact that this pathway controls the expression of the membrane ATP-binding cassette (ABC) transporter, multidrug resistance-associated protein 1, which extrudes chemotherapeutic drugs from leukemic cells and is usually associated with a lower survival rate [75, 76]. This evidence concerns the gene PIK3CA and acute myeloid leukemia.