Furthermore, interactions between β1 integrins on AML cells and stromal fibronectin could lead to pathway activation [92, 93], possibly through up-regulation of integrin-linked kinase 1 (ILK1) which is involved in Akt phosphorylation on Ser473 in a PI3K-dependent manner in AML cells [94]. This evidence concerns the gene PIK3CD and acute myeloid leukemia.