Hsp90 has also been implicated in the regulation and activation of Nod-like receptors (da Silva Correia et al., 2007; Mayor et al., 2007), the mammalian orthologs of the plant disease resistance proteins, revealing a conserved Hsp90-dependent mechanism of innate immunity in animals and plants (Shirasu, 2009; Ye and Ting, 2008). The gene discussed is HSP90AA1; the disease is glycogen storage disease VI.