Alarmed by one of our gynecologists who argued that our HER2 positivity rate of 9% of breast tumors (DIN1C-3, invasive carcinoma) was too low in contrast to most of the data presented in the literature (18-20%) [5,9,10], this researcher designed a study to reassess the routinely determined immunohistochemical HER2 status and to compare the immunohistochemical results with the gold standard dual color FISH, using PNBSs. This evidence concerns the gene ERBB2 and breast neoplasm.