The lack of statistical correlation between FOXP3 and CD25 expression, gated in a reproducible manner, lends weight to the argument that the elevated FOXP3 levels are not merely a marker of activated cells in HIV infection, in keeping with findings [70] describing dissociation between FOXP3 mRNA and CD25 expression in a SIV model. The gene discussed is FOXP3; the disease is HIV infectious disease.