Moreover, both P3 target antigen and PR1-CTL were found to be increased in CML patients that continued in CCR while receiving IFN as a single agent maintenance therapy after first achieving CCR during upfront treatment with IFN plus the bcr-abl tyrosine kinase inhibitor imatinib mesylate [29]. Here, TMEM37 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.