ACHE and early-onset autosomal dominant Alzheimer disease: AChE is found among neurofibrillary tangles and neuritic plaques[21] and its inhibition is an effective tool for the treatment of Alzheimer's disease and related Dementia.[22] Tacrine, a standard drug, exerts its pharmacological effect by increasing the acetylcholine level in the mouse brain.[23] All of the known acetylcholinesterase inhibiting drugs used in the therapy of AD suffers from several side effects such as high toxicity, short duration of biological action, low bioavailability and narrow therapeutic effects.