SETD2 and neoplasm: The transcription factor Hypoxia-Inducible Factor 1 (HIF-1) regulates the expressionof more than 70 genes involved in tumour angiogenesis, metabolic switch to anaerobicglycolysis, pro-survival, proliferative and apoptotic mechanisms [1].Overall, the expression of HIF-1 target genes helps cells to adapt to, and therebysurvive in, a stressful microenvironment.