Inthis context, we have previously demonstrated that under hypoxic conditions theoverexpression of bcl-2 in tumour cells is able to increase tumor angiogenesisenhancing the secretion of the pro-angiogenic factor VEGF, through the induction ofHIF-1α protein expression and HIF-1 transcriptional activity [12],[13]. The gene discussed is SETD2; the disease is neoplasm.