Inthis context we also found that overexpression of the anti-apoptotic andpro-survival protein bcl-2, in human melanoma and breast carcinoma cells, underhypoxia, enhances HIF-1α protein expression and HIF-1 activity consequentlyleading to angiogenesis through vascular endothelial growth factor (VEGF) [12],[13]. This evidence concerns the gene SETD2 and melanoma.