Effectors implicated in stimulating or suppressing an immuneresponse promote HIF-1α transcription [8]–[10], whereassome autocrine growth factors enhance translation of the HIF-1α protein[1].Indeed, the loss of function of tumour suppressors and the gain of function ofoncogenes also regulate different steps that lead to HIF-1 activation [1], [11]. The gene discussed is HIF1A; the disease is neoplasm.