The N-terminal region of PDCD10, which in some CCM patients is the site of an in-frame deletion of an entire exon encoding from L33 to K50, was found to be the binding site for the oxidant stress response serine/threonine kinase 25 (STK25) and the mammalian Ste20-like kinase 4 (MST4) [25]. The gene discussed is STK25; the disease is cerebral cavernous malformation.