Microglia are activated following in cerebral ischemia and express a variety of proinflammatory cytokines including interleukin -1β (IL-1β), interleukin -6 (IL-6) and tumor necrosis factor -α (TNF-α), which induce in neuroinflammation and neurotoxicity [5]–[8]. Here, TNF is linked to Cerebral ischemia.