SERPING1 and hereditary angioedema: AAE differs from HAE having absent family history, late onset of symptoms, usually low C1q antigen levels, prophylactic response to antifibrinolytics often better than to androgens, and sometimes requiring markedly higher doses of pdC1INH with rapid C1-INH catabolism and may respond to Icatibant or Ecallantide [10,24].