SERPING1 and hereditary angioedema: Originally referred to by clinical phenotype as estrogen-dependent (or estrogen-associated) inherited angioedema (EDIA, EAIA) [1], HAE with normal C1-INH activity [2]; or simply distinguished from classic forms as HAE type III [OMIM 610618] [2], the terms Factor XII-HAE or HAE-FXII have been used to identify the condition when associated with the recently identified gain-of-function mutation in the gene encoding factor XII (F 12) [11,12].