CREB1 and infection: 2). The linker histone H1F0, was downregulated with an increasing trend. Unlike the vast increase in histones expression, genes encoding major transcription regulators of histones expression such as CITED2, NCOA3, CREB1, YY1, and HDAC2 showed increasing suppression throughout infection. Similarly, many enzymes controlling major modifications of histones and chromatin organization dynamics of the host, including FBXO11, PRMT3, MYST2, MYCBP2, and RARS2 showed steady downregulation (Table. 2).