The MCF2L2 gene has the distances of 1,463 kb and 3,415 kb, respectively, to the location of SOX2 and ADIPOQ. In the present study, we found that SNP rs7639705 (T1165G Leu359Ile) in the MCF2L2 gene is significantly associated with decreased risk of DN in female T1DM patients in the GoKinD population. The gene discussed is SOX2; the disease is type 1 diabetes mellitus.