Elevated HO-1 has been detected in several cancer cell lines [3-6] and tumors (including lymphosarcoma, adenocarcinoma, hepatoma, glioblastoma, melanoma, prostate cancers, Kaposi sarcoma, squamous carcinoma, pancreatic cancer, brain tumors and myeloid leukemias; reviewed in [7]), thereby affecting tumor cell apotosis, proliferation, invasion and metastasis [7]. The gene discussed is HMOX1; the disease is melanoma.