Three proteins, B2M, alpha-1-acid glycoprotein 1 (ORM1), and insulin-like growth factor binding protein, acid labile subunit (IGFALS) have a FDR < 0.05 for association with CHD risk; and three proteins, apolipoprotein A-II precursor (APOA2), peptidyl-prolyl isomerase A (PPIA), and IGFBP4 have a FDR < 0.05 for association with stroke risk. The gene discussed is IGFALS; the disease is stroke disorder.