Logistic regression analyses that include a linear term in log IGFBP4 along with the case-control matching variables, hormone therapy randomization assignment, systolic and diastolic blood pressure, body mass index, and indicator variables for cigarette smoking, diabetes, and prior hormone therapy use yield a P-value of 0.018 for an association of IGFBP4 with stroke risk. The gene discussed is IGFBP4; the disease is Stroke.