In addition to these genes implicitly involved in mineralization, we also observed altered expression of genes normally expressed in heart or skeleton that are associated with cardiovascular or joint diseases including, DSP, THBS1, THBD and HGF, HGF binding protein (CLEC3B), ASPN, S100A4, SLC22A3, KCNK3, HHIP, Dkk1. Here, S100A4 is linked to arthropathy.