One of the first references to this effect was in work done by Vilcek and others 25 years ago, in which he found that of five tumor lines tested, two, an adenocarcinoma line and a rhabdomyosarcoma line, were highly sensitive to either purified natural or recombinant interferon-gamma even at concentrations of 1 unit/mL with the effect being abrogated by the addition of a specific monoclonal anti-interferon gamma antibody [69]. This evidence concerns the gene IFNG and rhabdomyosarcoma.