It has been shown that IFN-α can enhance the expression of the Epidermal Growth Factor Receptor (EGF-R) in some tumor cells (e.g. bladder cancer cell lines and KB cells) and that EGF can antagonize the apoptotic cell death induced by IFN-α and that IFN-α, in turn, can enhance the activity of EGF on certain cells [78,79,80]. This evidence concerns the gene IFNA1 and urinary bladder cancer.