Clinical trials are ongoing comparing the therapeutic efficacy of IFN-α or other cytokines (e.g., interleukin-2 and interleukin-12) with or without chemotherapeutics (e.g., vinblastine, cisplatin) in treating malignant melanoma in addition to those in which biologics (e.g. IFN-α, aldesleukin, IL-2) are administered subsequent to chemotherapy. This evidence concerns the gene IL2 and melanoma.