In 1987, Gutterman, et al. first addressed the use of IFN-α in the treatment of Chronic Myelogenous Leukemia (CML) and observed a 71% positive response rate in 51 patients treated with doses of 3 to 9 million international units (MIU) daily but it was not established as the standard of care for the disease until the early 1990s when it was determined to be better than standard chemotherapy by several randomized controlled trials [118]. This evidence concerns the gene IFNA2 and chronic myelogenous leukemia, BCR-ABL1 positive.