CEP290 and Leber congenital amaurosis: For example, RPGR exists in complex with NPHP5 (or IQ domain containing calmodulin binding protein [IQCB1]; SLSN), centrosomal protein of 290 kDa (CEP290)/NPHP6 (Leber congenital amaurosis, SLSN, JBTS), and NPHP8/RPGRIP1-like (RPGRIP1L; mutated in JBTS and Meckel-Gruber syndrome) in the retina [30–32].