OPA1 and glaucoma: Because we previously found that all neurons containing OPA1 immunoreactivity were co-labeled with FluoroGold-positive RGCs in a mouse model of glaucoma [14,38], we developed a gene therapy strategy using the transfection of a recombinant AAV2-WT mOPA1 construct to investigate whether overexpression of OPA1 increases RGC survival in glaucomatous DBA/2J mice with elevated IOP.