To examine this issue further and in the context of aging and AMD retinas, we concurrently obtained genotypes of human normal and AMD retinas and examined whether specific haplotypes or polymorphisms at 10q26 might be correlated to steady-state transcript levels of ARMS2 or HTRA1. In our study, none of the four polymorphisms (rs2736911, rs10490924, del443ins54, and rs11200638) either as homozygotes or heterozygotes or their associated haplotypes significantly affected the ARMS2 or HTRA1 gene expression levels. The gene discussed is ARMS2; the disease is age-related macular degeneration.