Here we confirmed prominent cathepsin D overexpression in the tauopathy model at early and advanced disease stages compared to age-matched control animals using quantitative PCR (fold-change, 1.6 with P = 0.005, and 2 with P = 0.037, respectively; Figure S1), thus recapitulating findings from Alzheimer's disease patients. This evidence concerns the gene CTSD and early-onset autosomal dominant Alzheimer disease.