The pathways that received the most support were: DNA damage response and BRCA1 gene, aryl hydrocarbon receptor (AHR) signaling, ATM signaling, G2/M DNA damage checkpoint regulation, mitotic roles of polo-like kinase (PLK), role of CHK proteins in cell-cycle checkpoint control, purine metabolism, molecular mechanisms of cancer, G1/S checkpoint regulation, and P53 signaling (Table 3). This evidence concerns the gene PLK1 and cancer.