FOXE3 and microphthalmia: Since previous reports with homozygous FOXE3 mutations described sclerocornea in association with aphakia and microphthalmia [5-7], magnetic resonance imaging (MRI) was used to examine the eyes in 2 affected individuals from the Pakistani family and ultrasound was used to examine the eyes in 5 affected individuals from the Mexican pedigree (Figure 4).