Tanhehco et al. [34] reported a spontaneous R124L mutation in TGFBI in 2 patients with CDRB, and Zhao et al. [35] reported a spontaneous R555Q mutation in TGFBI in two unrelated families with Bowman's layer corneal dystrophies (CDTB and CDRB). This evidence concerns the gene TGFBI and corneal dystrophy.