ANO1 and head and neck squamous cell carcinoma: The ANO1 gene is located on 11q13 (Katoh and Katoh, 2003), a chromosomal region that is frequently amplified in HNSCC and is associated with poor outcome (for reviews, see Gollin, 2001; Katoh and Katoh, 2003; West et al, 2004; Perez-Ordonez et al, 2006; Espinosa et al, 2008; Haddad and Shin, 2008).