This led to the identification of a novel uncharacterised gene located on chromosomal region 11q13 that is overexpressed in HNSCC, which is now called anoctamin 1 (ANO1, also called TMEM16A, ORAOV2, DOG1, TAOS2 and FLJ10261). This evidence concerns the gene ANO1 and head and neck squamous cell carcinoma.