When other known variables for prognosis of endometrial cancer, including FIGO stage, pathological grade and myometrial invasion, were included in a Cox proportional hazard analysis for relapse-free survival, HER-2 expression (hazard ratio 5.31, P=0.0180) and FIGO stage were identified as independent predictive factors of patient survival (Table 5). The gene discussed is ERBB2; the disease is endometrial cancer.