We first investigated the expression of EGFR family members EGFR, HER-2 and HER-4 by immunohistochemistry using 63 surgical specimens of endometrioid-type endometrial cancers, on the basis of the known finding that HER-3 expression is not upregulated in endometrial cancer (Ejskjaer et al, 2007). This evidence concerns the gene ERBB4 and endometrial cancer.