The lack of correlation between expression on IHC and outcome is fully consistent with the previous report by Heinrich et al. Interestingly, Tabone-Eglinger et al (2008) have shown that GIST-type KIT mutations induce an activation-dependent alteration of normal maturation and trafficking, resulting in the intracellular retention of the activated kinase within the cell. This evidence concerns the gene KIT and gastrointestinal stromal tumor.