The reduction in VEGF and MMP-9 expressions by macrophages under the influence of ZA has been described to prevent tumour neovascularisation (Santini et al, 2002; Giraudo et al, 2004; Vincenzi et al, 2005; Melani et al, 2007; Tsagozis et al, 2008). The gene discussed is VEGFA; the disease is neoplasm.