TNFSF10 and cancer: Since TRAIL as a targeted cancer therapy preferentially kills cancer versus normal cells [20], we compared the cytotoxic and apoptotic effects of TRAIL between CEM human lymphoblastic leukemic cell line and its multidrug resistant (MDR) variants, including CEM/VLB10-2, CEM/VLB55-8, and CEM/VLB100 isolated from parental CEM cells.