In a study of the clinical manifestations associated with mutations in the calcium- channel, voltage dependent, P/Q type, alpha A subunit gene (CACNA1A) in 28 families with Familial Hemiplegic Migraine type 1, Ducros et al (2001) [3], revealed significant genotype-phenotype correlations. The gene discussed is CACNA1A; the disease is familial or sporadic hemiplegic migraine.