MEN1 and adenocarcinoma: The intensity of the wild-type allele (+), but not the mutant allele (-), was reduced in two mPINs (PIN1 and 2, both showing reduction of menin expression by IHC analysis) and in an adenocarcinoma lesion (ADC) from Men1+/- mice, as demonstrated by the lower +/- ratios for these lesions when compared with the control (Figure 2J).