In order to determine whether stabilization of Snail by macrophages/IL-1β contributes to their ability to drive Wnt signaling, we silenced Snail in tumor cells (Fig. 7B), and examined the ability of macrophages and IL-1β to induce Wnt signaling in Snail deficient HCT116 and Hke-3 cells. This evidence concerns the gene IL1B and neoplasm.