NFKB1 and colonic neoplasm: Coordinated signaling between tumor cells and nonmalignant cells in the tumor microenvironment is required for the progression of tumors, and signaling pathways that regulate the crosstalk between colon tumor cells and stroma, such as NF-κB and STAT3, have emerged as important targets for chemopreventive and chemotherapeutic agents [3], [4].