CDH1 and neoplasm: In the ApcMin mouse model of intestinal tumorigenesis, inhibition of Snail increased cell death and reduced tumor formation [52] and in human tumors, nuclear β-catenin activity is enhanced at the invasive front, where the expression of E-cadherin, a direct target of Snail, is downregulated [53], suggesting that this positive regulatory signaling is functional in vivo.