TNFSF10 and intestinal polyp: Recently, the combination of TRAIL with all trans-retinyl acetate (RAc) has been shown to induce apoptosis selectively in adenomatous polyposis (APC) deficient epithelial cell without harming normal cellsαα and treatment of ApcMin mice with TRAIL and RAc induced apoptosis in intestinal polyps and prolonged animal survival [12].