PDC and infection: The resulting calibrated model for the in vitro pDC response to MHV was further validated by comparing its predictions with in vitro infection at an MOI of 0.1 and 0.01 (Figure S1) and also, by determining the fraction of infected cells deduced from experimental data sets using an enhanced green fluorescence protein (EGFP) expressing recombinant MHV [10] (Figure 2A and B).