Figure 8B shows that about 60% of the IPS-1+/+ or +/− mice lived, while only 45% of the IPS-1 −/− mice survived infection. More dramatically, nearly 90% of the IPS-1−/− mice had hind limb paralysis 11 days post infection while the IPS-1+/+ and +/− mice exhibited only about 45% paralysis (Figure 8C). The gene discussed is MAVS; the disease is infection.