LYN and leukemia: Table 1 highlights 9 of the phosphoproteins detected with previous links to CLL/leukemia, including Hematopoietic cell-specific Lyn substrate (Hcls1) and SH2-containing inositol phosphatase-1 (SHIP-1). The phosphorylation status of both Hcls1 and SHIP-1 have been shown to correlate with disease aggressiveness and shorter mean survival [17], [18], [19], consistent with the aggressive characteristics of CLL A.