Previously observed associations of rs780094 and metabolic traits reached statistical significance among white participants in univariate analyses: each additional copy of the T-allele was associated with higher triglyceride (p = 5×10−22), CRP (p = 3×10−8), and post-OGTT glucose levels (p = 0.009), higher prevalence of the metabolic syndrome (p = 0.016), and with lower fasting glucose (p = 0.002), fasting insulin (p = 0.007) and HOMA-IR (p = 0.006). Here, INS is linked to metabolic syndrome.