INS and Insulin resistance: Common variants in GCKR, most often the minor T-allele of the common single nucleotide polymorphism (SNP) rs780094, have been reported by multiple candidate gene and GWA studies to be associated with decreased fasting glucose[12]–[19] and insulin levels [12], [16], [18], lower insulin resistance[12], [15]–[18], [20], and decreased prevalence of type 2 diabetes [12], [15], [16], [18].