AVP and Polyuria: Management strategies for NDI and polyuria include dose reduction, single daily dosing, potassium supplementation, use of amiloride (which blocks the entry of lithium to ADH-sensitive epithelia and enhances ADH action) or hydrochlorothiazide, use of desmopressin and use of indomethacin (as high levels of PGE2 have been found in NDI).[11]