To date TGF-β-independent functions for mammalian SnoN have been identified in myoblasts [30] and cerebellar neurons [31] in culture and Ski has been found to associate with β-catenin in human melanoma cells [32] but no Sno family member has been reported to impact Wg signaling during development in any species. The gene discussed is TGFB1; the disease is melanoma.