TNF and type 2 diabetes mellitus: In addition to the wealth of literature available on endothelial damage and cardiovascular events, recent studies have shown that systemic inflammation markers such as ferritin [3], fibrinogen [21,22], and C-RP are increased in subjects with type 2 diabetes as indicators of prognosis, as well as inflammation mediators associated with insulin resistance such as IL-1, IL-6, and TNF-α [23].