Genotype at the SNPs in PTPRM and LRRC20 showed a statistically significant relationship with serum IFN-α in SLE patients when ancestral backgrounds were analyzed in aggregate (P = 2.2 × 10-6 and P = 2.6 × 10-3 respectively, both exceeding Bonferroni threshold P-value of 7.1 × 10-3, Figure 1). The gene discussed is LRRC20; the disease is systemic lupus erythematosus.